PGT-M

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PGT-M (Preimplantation Genetic Testing for Monogenic Disorders) is an advanced genetic test performed during IVF to detect specific inherited diseases in embryos before implantation. It is mainly recommended for couples who carry a known genetic mutation or have a family history of hereditary disorders. During the IVF process, a few cells are gently taken from each embryo and tested for the targeted condition, and only healthy embryos without the genetic disorder are selected for transfer, helping increase the chances of a healthy pregnancy.

Who Needs PGT-M?

PGT-M is recommended for couples who are known carriers of specific genetic disorders or have a family history of inherited diseases such as thalassemia, cystic fibrosis, or sickle cell anemia. It is also advised for individuals who have previously had a child affected by a genetic condition or experienced repeated pregnancy losses due to inherited disorders. PGT-M helps such couples reduce the risk of passing the genetic disease to their baby and supports safer family planning.

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Benefits of PGT-M

PGT-M helps reduce the risk of passing inherited genetic disorders to the baby by selecting healthy embryos before implantation. It increases the chances of a successful and healthy pregnancy, lowers the emotional stress associated with genetic risks, and supports informed family planning decisions. By ensuring that only unaffected embryos are transferred, PGT-M provides reassurance and confidence to couples with a history of hereditary conditions.

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PGT-M Technology

PGT-M testing involves a detailed analysis of the specific genetic mutation carried by an individual, along with the surrounding region of the chromosome (often represented as a colored segment). Since every family’s genetic pattern is unique, each PGT-M test is specially designed for that particular couple. To accurately develop the test, DNA samples from both partners—and sometimes additional family members are required.
Once the test design is completed, a method called linkage analysis is used to identify the unique “genetic fingerprint” associated with the mutation. This allows specialists to accurately determine whether each tested embryo is affected or unaffected by the inherited condition.

PGT-M process

The PGT laboratory collects DNA samples from both partners and, when necessary, from relevant family members to develop a customized genetic test that is uniquely designed for each family.

Step 01

Embryo Biopsy & Genetic Testing

A few cells are carefully taken from each embryo and tested in a specialized genetic lab to check for the specific inherited disorder.

Step 02

Healthy Embryo Transfer

Embryos that are free from the targeted genetic condition are selected and transferred into the uterus to increase the chances of a healthy pregnancy.

Step 03

Frequently asked question

1. What is PGT-M?

PGT-M is a specialized genetic test performed during IVF to detect specific inherited (single-gene) disorders in embryos before they are transferred to the uterus.

2. Why is PGT-M recommended?

It is recommended for couples who are carriers of genetic diseases or have a family history of inherited conditions to reduce the risk of passing the disorder to their baby.

3. How accurate is PGT-M testing?

PGT-M is highly accurate in detecting the targeted genetic mutation, as the test is specifically designed for each family’s unique genetic pattern.

4. Does PGT-M guarantee pregnancy?

PGT-M helps select embryos free from the specific genetic disorder, but overall pregnancy success also depends on factors like maternal age, embryo quality, and overall health.

5. Is PGT-M safe for embryos?

The embryo biopsy is performed by experienced specialists using advanced techniques. When done in a certified lab, it is considered safe and does not affect normal embryo development.

04035100400

Hyderabad

Hanamkonda